ea0063p665 | Interdisciplinary Endocrinology 1 | ECE2019
Ascani Angelo
, Gumpold Roswitha
, Borzan Valentin
, Flieszer Elisabeth
, Weber Jennifer
, Prietl Barbara
, Helmut Stradner Martin
, Obermayer-Pietsch Barbara
Background: Age-associated double negative (DN) B memory cells lacking surface expression of CD27 and IgD have been associated with proinflammatory characteristics, higher disease activity in autoimmune diseases and disease-specific autoantibodies. We studied the distribution of DN B cells in Polycystic Ovary Syndrome (PCOS), their surface markers and cytokine production.Methods: CD19+ cell subpopulations on the basis of IgD and CD27 expression were phen...